University Children Hospital, Pediatrics, Gastroenterology and Allergology Department, Medical University of Bialystok, Bialystok, Poland.
J Aerosol Med Pulm Drug Deliv. 2012 Jun;25(3):154-8. doi: 10.1089/jamp.2011.0917. Epub 2012 Jan 26.
Concentration of nitric oxide in exhaled air (FeNO) was revealed to decrease as a result of immunotherapy. However, individuals who are exposed to environmental allergens are characterized by elevated values of FeNO. The aim of this study was to analyze the effects of subcutaneous immunotherapy (SCIT) on the dynamics of FeNO determined during consecutive pollination seasons.
This study, performed between 2005 and 2008, included 41 patients with confirmed sensitivity to grass pollens and predominating symptoms of seasonal allergic rhinitis, randomly assigned to desensitization by preseasonal or maintenance SCIT. FeNO was measured prior to and during each pollen season (November-January and May-July, respectively). The results were conferred to data on grass pollination intensity in 2006-2008 (air concentration of grass pollen grains, seasonal number of days when air concentration of grass pollen reached at least 50 grains per 1 m(3)).
Median content of FeNO in exhaled air was significantly higher in 2007 compared to 2006 and 2008 pollen seasons. During 2007 and 2008 pollen seasons, significant increase in FeNO was observed compared to the respective preseasonal values. Median number of days with air concentration of grass pollen ≥ 50 grains per 1 m(3) of air during 4 weeks preceding seasonal FeNO measurement was significantly higher in 2007, corresponding to higher FeNO value recorded during this pollen season. However, no significant correlation was observed between seasonal number of days with ≥ 50 grass pollen grains per 1 m(3) of air and FeNO in exhaled air (r=0.09, p=0.362).
Most seasonal allergic rhinitis patients show physiological levels of FeNO prior to the pollen seasons and a marked increase in this parameter, probably proportional to pollination intensity, is observed within the seasons. ISRCTN Registry: ISRCTN86562422.
呼气中一氧化氮浓度（FeNO）的浓度已被证明会随着免疫疗法而降低。然而，暴露于环境过敏原的个体的 FeNO 值会升高。本研究的目的是分析皮下免疫疗法（SCIT）对连续花粉季节中测定的 FeNO 动态的影响。
本研究于 2005 年至 2008 年进行，包括 41 例经证实对草花粉敏感且主要表现为季节性过敏性鼻炎的患者，随机分配进行 preseasonal 或维持性 SCIT 脱敏。在每个花粉季节（分别为 11 月至 1 月和 5 月至 7 月）之前和期间测量 FeNO。结果与 2006-2008 年的草花粉授粉强度数据相关（空气中草花粉粒的浓度，空气中草花粉浓度达到至少每立方米 50 粒的季节天数）。
与 2006 年和 2008 年花粉季节相比，2007 年呼气中 FeNO 的中位数含量明显更高。与相应的 preseasonal 值相比，在 2007 年和 2008 年花粉季节中观察到 FeNO 显著增加。在季节性 FeNO 测量前的 4 周内，空气中草花粉浓度≥每立方米 50 粒的天数中位数在 2007 年更高，与该花粉季节记录的更高 FeNO 值相对应。然而，空气中≥每立方米 50 粒草花粉的季节性天数与呼气中的 FeNO 之间没有观察到显著相关性（r=0.09，p=0.362）。
大多数季节性过敏性鼻炎患者在花粉季节前显示出生理水平的 FeNO，并且在季节内观察到该参数的显著增加，可能与授粉强度成正比。ISRCTN 注册处：ISRCTN86562422。
