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明胶 β-三钙磷酸盐海绵和骨形态发生蛋白-2 对马第三掌骨缺损的体内成骨活性。

In vivo osteoinductivity of gelatin β-tri-calcium phosphate sponge and bone morphogenetic protein-2 on an equine third metacarpal bone defect.

机构信息

Department of Clinical Veterinary Science, Obihiro University of Agriculture Veterinary Medicine, Obihiro-city, Hokkaido 080-8555, Japan.

出版信息

Res Vet Sci. 2012 Oct;93(2):1021-5. doi: 10.1016/j.rvsc.2011.12.002. Epub 2012 Jan 24.

DOI:10.1016/j.rvsc.2011.12.002
PMID:22280550
Abstract

This study evaluated the therapeutic effects of a gelatin-β-TCP sponge (sponge) incorporating BMP-2 (BMP-2/sponge) on bone regeneration in equines. Six bone defects were created in third metacarpals of five thoroughbred horses, and a total of six treatments were applied in a randomized manner. The treatments were BMP-2/sponge, BMP-2/gelatin hydrogel sheet (sheet), free BMP-2, bFGF/sheet, plain sponge, and plain sheet. The defects were monitored for 16 weeks by radiography and then examined by histological analysis. Radiographic evaluation scores of bone regeneration revealed significantly greater bone regeneration of defects treated with BMP-2/sponge than defects treated with plain sponge or BMP-2 sheet (P<0.05). In histological analysis, compact bone was observed over a wide area in the BMP-2/sponge treatment. We concluded that the treatment with BMP-2/sponge accelerated bone regeneration in the equines of this study.

摘要

本研究评估了包埋骨形态发生蛋白 2（BMP-2）的明胶-β-TCP 海绵（海绵）在马骨再生中的治疗效果。在五匹纯血马的第三掌骨中创建了六个骨缺损，并以随机方式共应用了六种治疗方法。这些治疗方法分别为 BMP-2/海绵、BMP-2/明胶水凝胶片（片）、游离 BMP-2、bFGF/片、普通海绵和普通片。通过放射学监测骨再生 16 周，然后通过组织学分析进行检查。骨再生的放射学评估评分显示，BMP-2/海绵治疗的缺陷的骨再生明显大于普通海绵或 BMP-2 片治疗的缺陷（P<0.05）。在组织学分析中，在 BMP-2/海绵治疗中观察到大面积的密质骨。我们得出结论，BMP-2/海绵的治疗加速了本研究中马的骨再生。

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