Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
Radiother Oncol. 2012 May;103(2):161-5. doi: 10.1016/j.radonc.2011.12.012. Epub 2012 Jan 24.
To report the incidence of clinical, pathological and radiological fat necrosis (FN) in women treated with accelerated partial breast irradiation (APBI) using interstitial brachytherapy (BRT) for early-stage breast cancer and to study certain variables associated with it.
Between May 2000 and August 2008, 171 women were treated with APBI using high dose rate (HDR) BRT. Patients were treated to a dose of 34 Gy/10 fractions/1 week with two fractions/day after intraoperative/postoperative placement of catheters.
At a median follow up of 48 months (SD: 28) 20 women developed FN with median time to detection being 24 months (range: 4-62 months, SD: 20). Actuarial 5 and 7 year FN rate was 18% and 23%, respectively. Grade 1 FN was seen in 4, grade 2 in 8 and grade 4 in 8 women. Additional investigations such as aspiration/biopsy were done in 9 patients. Volume of excision was the only significant factor affecting FN (p=0.04).
Actuarial FN rate of 18% at 5 years in our study was comparable to other reported series of FN. Median time of detection of FN was 24 months. Higher volume of excision resulted in an increased incidence of fat necrosis.
报告在接受早期乳腺癌间质近距离放射治疗（BRT）加速部分乳房照射（APBI）的女性中，临床、病理和放射学脂肪坏死（FN）的发生率，并研究与之相关的某些变量。
在 2000 年 5 月至 2008 年 8 月期间，171 名女性接受了高剂量率（HDR）BRT 的 APBI 治疗。患者接受 34 Gy/10 次分割/1 周的剂量治疗，每天两次放置导管后进行术中/术后治疗。
在中位随访 48 个月（标准差：28）时，20 名女性发生 FN，中位检测时间为 24 个月（范围：4-62 个月，标准差：20）。5 年和 7 年的 FN 发生率分别为 18%和 23%。1 级 FN 见 4 例，2 级 8 例，4 级 8 例。对 9 名患者进行了抽吸/活检等进一步检查。切除体积是唯一影响 FN 的显著因素（p=0.04）。
我们研究中 5 年的 FN 发生率为 18%，与其他 FN 报道的系列相似。FN 的中位检测时间为 24 个月。更大的切除体积导致脂肪坏死的发生率增加。
