Institut Curie, CNRS-UMR144, Paris 75005, France.
Curr Biol. 2012 Jan 24;22(2):R52-4. doi: 10.1016/j.cub.2011.12.007.
Directional transport of specific cargos is tuned to specific molecular motors and specific cytoskeletal tracks. Myosin V transports its cargo on actin cables, whereas kinesin or dynein transport their cargo on microtubules. A recent study shows that an engineered kinesin can substitute for myosin V and its cargo-specific transport and subsequent cellular functions.
特定货物的定向运输被调整到特定的分子马达和特定的细胞骨架轨道。肌球蛋白 V 可在肌动蛋白电缆上运输其货物，而驱动蛋白或动力蛋白则可在微管上运输其货物。最近的一项研究表明，一种工程化的驱动蛋白可以替代肌球蛋白 V 及其货物特异性运输以及随后的细胞功能。
