Department of Food Engineering, Central Food Technological Research Institute, CSIR, Mysore 570 020, India.
J Biosci Bioeng. 2012 May;113(5):634-40. doi: 10.1016/j.jbiosc.2011.12.021. Epub 2012 Jan 27.
A techno-economic analysis of submerged (SmF) and solid state fermentation (SSF) processes for Aspergillus carbonarius polygalacturonase production was performed to make an appropriate process selection. The downstream processing involved integrated membrane process (IMP) and alginate affinity precipitation (AAP). For a production scale of 30kL purified polygalacturonase concentrate per year, the total upstream cost of SmF was 14% lower than the SSF process. Downstream processing cost by IMP was 47% lower than AAP. The SmF-IMP process required a total capital investment that was 15-24% lower than the SmF-AAP and SSF-AAP processes. The corresponding unitary product cost was also lower by 24-36% in SmF-IMP process. Thus the SmF-IMP process proved to be very attractive from an economic point of view.
对固态发酵（SSF）和浸没发酵（SmF）生产曲霉属多聚半乳糖醛酸酶的技术经济分析，以进行适当的工艺选择。下游处理涉及集成膜过程（IMP）和海藻酸盐亲和沉淀（AAP）。对于每年 30kL 纯化的多聚半乳糖醛酸酶浓缩物的生产规模，SmF 的总上游成本比 SSF 工艺低 14%。IMP 的下游处理成本比 AAP 低 47%。SmF-IMP 工艺的总资本投资比 SmF-AAP 和 SSF-AAP 工艺低 15-24%。相应的单位产品成本也降低了 24-36%。因此，从经济角度来看，SmF-IMP 工艺具有很大的吸引力。
