Berger Aaron J, Son Ji, Desai Nikhil K
Division of Plastic Surgery, Department of Surgery, Stanford University Medical Center, Palo Alto, CA, USA.
J Oral Maxillofac Surg. 2012 Oct;70(10):2316-26. doi: 10.1016/j.joms.2011.11.004. Epub 2012 Jan 24.
Malignant ameloblastoma is a rare tumor of odontogenic origin with a metastatic focus. Distant metastatic disease is found most commonly in the lungs. A review of the literature shows that most cases of malignant ameloblastoma involve a disease-free period from primary tumor extirpation to the discovery of metastasis. This report describes the case of a 56-year-old man presenting with ameloblastoma of the maxilla and a solitary pulmonary metastasis concurrently. This represents a rare case in which there is a simultaneous diagnosis of primary ameloblastoma and a metastatic lesion. Appropriate workup for ameloblastoma includes surveillance for metastatic disease. Surgical resection of primary and distant disease is recommended. Chemotherapy and radiation may play a role in palliation when resection of metastatic disease is not feasible.
恶性成釉细胞瘤是一种罕见的牙源性肿瘤，伴有转移灶。远处转移最常见于肺部。文献回顾显示，大多数恶性成釉细胞瘤病例在原发性肿瘤切除至转移发现之间有一段无病期。本报告描述了一名56岁男性同时出现上颌骨成釉细胞瘤和孤立性肺转移的病例。这是一例罕见的同时诊断原发性成釉细胞瘤和转移病灶的病例。成釉细胞瘤的适当检查包括对转移疾病的监测。建议对原发性和远处疾病进行手术切除。当转移疾病无法切除时，化疗和放疗可能在缓解病情方面发挥作用。
