危重病相关性贫血：病因学、后果和管理的新视角。
Anemia in critical illness: insights into etiology, consequences, and management.
机构信息
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, USA.
出版信息
Am J Respir Crit Care Med. 2012 May 15;185(10):1049-57. doi: 10.1164/rccm.201110-1915CI. Epub 2012 Jan 26.
Abstract
Anemia is common in the intensive care unit, and may be associated with adverse consequences. However, current options for correcting anemia are not without problems and presently lack convincing efficacy for improving survival in critically ill patients. In this article we review normal red blood cell physiology; etiologies of anemia in the intensive care unit; its association with adverse outcomes; and the risks, benefits, and efficacy of various management strategies, including blood transfusion, erythropoietin, blood substitutes, iron therapy, and minimization of diagnostic phlebotomy.
摘要
贫血在重症监护病房中很常见，可能与不良后果有关。然而，目前纠正贫血的方法并非没有问题，并且目前缺乏令人信服的疗效来改善重症患者的生存。本文综述了正常红细胞生理学；重症监护病房贫血的病因；与不良结局的关系；以及各种管理策略的风险、益处和疗效，包括输血、促红细胞生成素、血液替代品、铁剂治疗和减少诊断性采血。
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本文引用的文献
1
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N Engl J Med. 2011 Dec 29;365(26):2453-62. doi: 10.1056/NEJMoa1012452. Epub 2011 Dec 14.
2
Organ-protective and immunomodulatory effects of erythropoietin--an update on recent clinical trials.促红细胞生成素的器官保护和免疫调节作用——近期临床试验的最新进展
Basic Clin Pharmacol Toxicol. 2012 Feb;110(2):113-21. doi: 10.1111/j.1742-7843.2011.00820.x. Epub 2011 Nov 9.
3
Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock.红细胞输注与急性肺损伤、脓毒症和休克患者的结局。
Crit Care. 2011;15(5):R221. doi: 10.1186/cc10458. Epub 2011 Sep 21.
4
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.红细胞微粒和无细胞血红蛋白清除一氧化氮作为红细胞储存损伤的机制。
Circulation. 2011 Jul 26;124(4):465-76. doi: 10.1161/CIRCULATIONAHA.110.008698. Epub 2011 Jul 11.
5
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6
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Anesth Analg. 2010 Dec;111(6):1424-6. doi: 10.1213/ANE.0b013e3181fc74b9. Epub 2010 Nov 3.
7
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JAMA. 2010 Oct 13;304(14):1559-67. doi: 10.1001/jama.2010.1446.
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Transfusion. 2011 Mar;51(3):610-21. doi: 10.1111/j.1537-2995.2010.02861.x. Epub 2010 Aug 24.
9
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Anesthesiology. 2010 Jul;113(1):92-103. doi: 10.1097/ALN.0b013e3181de6f25.
10
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Circ Cardiovasc Qual Outcomes. 2010 Jul;3(4):337-46. doi: 10.1161/CIRCOUTCOMES.110.957050. Epub 2010 May 20.
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