Zarrindast M R, Naghashi H
Department of Pharmacology, Medical Faculty, University of Tehran, Iran.
J Psychopharmacol. 1991 Jan;5(2):160-5. doi: 10.1177/026988119100500211.
The effect of the mixed D-1/D-2 dopamine agonist apomorphine, the D-2 agonist bromocriptine and the D- 1-selective dopamine agonist SKF 38393 on sniffing behaviour in rats was tested in the present experiments. Apomorphine induced a dose-dependent sniffing, which was decreased by either D-2 or D-1 dopamine antagonist pre-treatment. Atropine (antimuscarinic drug) or phenoxybenzamine and propranolol (α and β- adrenergic blockers, respectively) did not alter the apomorphine response. Apomorphine induced a significant increase in sniffing in reserpine-treated animals. Bromocriptine produced sniffing during the 3rd hour after drug injection. The effect was decreased by sulpiride or SCH 23390 pre-treatment. Phenoxybenzamine or propranolol did not change the bromocriptine effect, while atropine increased the drug response. SKF 38393 also induced a slight but significant sniffing. In rats pre-treated with reserpine, neither bromocriptine nor the D-1-selective agonist SKF 38393 produced any sniffing. However, the combination of bromocriptine with SKF 38393 produced an intense sniffing behaviour. It may be concluded that bromocriptine requires D-1 receptor stimulation for the expression of sniffing.
在本实验中，测试了混合的D-1/D-2多巴胺激动剂阿扑吗啡、D-2激动剂溴隐亭和D-1选择性多巴胺激动剂SKF 38393对大鼠嗅探行为的影响。阿扑吗啡诱导剂量依赖性的嗅探，D-2或D-1多巴胺拮抗剂预处理可使其降低。阿托品（抗胆碱能药物）或酚苄明及普萘洛尔（分别为α和β肾上腺素能阻滞剂）未改变阿扑吗啡反应。阿扑吗啡使利血平处理的动物嗅探显著增加。溴隐亭在注射药物后第3小时引起嗅探。舒必利或SCH 23390预处理可降低该效应。酚苄明或普萘洛尔未改变溴隐亭的效应，而阿托品增加了药物反应。SKF 38393也诱导轻微但显著的嗅探。在用利血平预处理的大鼠中，溴隐亭和D-1选择性激动剂SKF 38393均未产生任何嗅探。然而，溴隐亭与SKF 38393联合使用产生强烈的嗅探行为。可以得出结论，溴隐亭需要D-1受体刺激来表达嗅探。
