Effects of paroxetine and maprotiline on mood, perceptual-motor skills and eye movements in healthy volunteers.

Sixteen healthy young volunteers (seven females, nine males) received repeated doses of either 30 mg paroxetine, 100 mg maprotiline or placebo in a double-blind crossover study. Each of the three treatments lasted 1 week separated by 2 weeks of no treatment. Treatment order was counterbalanced. Subjects were tested before each treatment period, and after 1 and 7 days of treatment. Measurements were made of mood, perceptual-motor skills, and eye movements including pupil size when subjects were watching a traffic film.