Warot D, Danjou P, Lacomblez L, Diquet B, Puech A J
Therapie. 1989 Jul-Aug;44(4):257-61.
The effects on psychomotor and mnesic performance of acute oral doses of maprotiline (25, 50 and 75 mg) were evaluated in twelve healthy men in a placebo-controlled double blind study. A battery of tests was performed comprising: objective measures (critical flicker frequency, choice reaction time, memory tasks) and self rating evaluation (visual analogue scales). Tests session took place 15 hours after each treatment. Plasma concentrations of maprotiline were determined. Compared with placebo, maprotiline induced psychomotor impairment on both objective and subjective assessment in a dose related manner. No significant difference between maprotiline and placebo on memory test could be evidenced.
在一项安慰剂对照的双盲研究中，对12名健康男性评估了急性口服不同剂量（25毫克、50毫克和75毫克）马普替林的精神运动和记忆功能影响。进行了一系列测试，包括：客观测量（临界闪烁频率、选择反应时间、记忆任务）和自我评分评估（视觉模拟量表）。每次治疗后15小时进行测试。测定了马普替林的血浆浓度。与安慰剂相比，马普替林在客观和主观评估中均以剂量相关的方式引起精神运动损害。在记忆测试中，马普替林与安慰剂之间没有显著差异。
