Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA.
Oncologist. 2012;17(2):274-8. doi: 10.1634/theoncologist.2011-0198. Epub 2012 Jan 26.
Bevacizumab, a monoclonal antibody targeting a vascular endothelial growth factor (VEGF) protein, has been reported to induce mucosal toxicities. However, the clinical characteristics of these particular toxicities have not been well characterized. We aimed at providing a detailed clinical description of signs and symptoms limited to the tongue mucosa in patients treated with bevacizumab.
A retrospective review of medical records and clinical photographs was performed with specific attention to clinical presentation, evolution, associated symptoms, concomitant medications, and treatment methods.
In total, four patients presented to the dermatology service with clinical findings characterized by multifocal, erythematous circinate and serpiginous erosions on the dorsal tongue surrounded by white hyperkeratotic rims that were temporally related to bevacizumab therapy. Associated increased sensitivity to spicy foods was frequently observed.
These characteristic clinical findings are consistent with geographic tongue. However, large prospective evaluations are necessary to confirm this potential relationship. If bevacizumab is indeed associated with geographic tongue, increased awareness may result in improved reporting and characterization of this particular adverse event.
贝伐单抗是一种针对血管内皮生长因子（VEGF）蛋白的单克隆抗体，据报道可引起黏膜毒性。然而，这些特定毒性的临床特征尚未得到很好的描述。我们旨在详细描述接受贝伐单抗治疗的患者舌黏膜局限性的体征和症状。
对病历和临床照片进行回顾性审查，重点关注临床表现、演变、伴随症状、同时使用的药物和治疗方法。
共有 4 名患者因舌背多灶性红斑性环状和匐行性糜烂，周围有白色角化过度的边缘，这些与贝伐单抗治疗有时间相关性，而就诊于皮肤科。常伴有对辛辣食物的敏感性增加。
这些特征性的临床发现与地图舌一致。然而，需要进行大规模前瞻性评估以确认这种潜在的关系。如果贝伐单抗确实与地图舌有关，那么提高认识可能会导致对此类特定不良事件的更好报告和描述。
