Maraschin J, Dutrillaux B, Aurias A
C.N.R.S. URA 620, Institut Curie, Section de Biologie, Paris, France.
Int J Cancer. 1990 Nov 15;46(5):808-12. doi: 10.1002/ijc.2910460511.
The clastogenic effect of etoposide, an anti-cancer chemotherapeutic drug, was investigated in vitro on lymphocytes of 5 healthy donors. The analysis of the first division metaphases arising after mutagenesis in G1 phase shows that chromosome-type aberrations are much more frequent than chromatid-type lesions. The distribution in relation to chromosome lengths of the 439 breakpoints that were accurately identified is not random: chromosomes 1, 11 and 17 are most frequently involved, while chromosomes 4, 5 and X are seldom affected. This non-random distribution may be related to chromosome structure, since R-band-rich chromosomes are significantly more affected than G-band-rich chromosomes.
对5名健康供体的淋巴细胞进行体外研究，以探究抗癌化疗药物依托泊苷的致断裂效应。对G1期诱变后出现的首次分裂中期进行分析表明，染色体型畸变比染色单体型损伤更为常见。准确识别的439个断点在染色体长度上的分布并非随机：1号、11号和17号染色体最常受累，而4号、5号染色体和X染色体很少受到影响。这种非随机分布可能与染色体结构有关，因为富含R带的染色体比富含G带的染色体受影响明显更大。
