Wang Haojie, Shuraih Mossaab, Ahmad Masood
Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555-0553, USA.
Echocardiography. 2012 Feb;29(2):192-9. doi: 10.1111/j.1540-8175.2011.01622.x.
Left ventricular (LV) mechanical dyssynchrony is an important prognostic marker for higher morbidity and mortality in patients with symptomatic heart failure. However, the response rate to resynchronization varies among patients meeting current guidelines for Cardiac resynchronization therapy (CRT). Two-dimensional echocardiography and Doppler-based techniques have shown variable results in the assessment of LV dyssynchrony. There is an obvious need for a noninvasive tool that can reliably measure LV dyssynchrony. Accurate prediction of response to CRT will improve patient selection for such therapy. Real time three-dimensional echocardiography (RT3DE) is a novel noninvasive imaging modality that has been recently used in quantitative evaluation of global and regional LV function. A number of published studies have described the use of RT3DE in the measurement of LV dyssynchrony in patients with normal or reduced LV function. The systolic dyssynchrony index derived from RT3DE has been used to quantify LV dysynchrony and to evaluate and predict the response to CRT. This review will discuss the recently published data regarding the role of RT3DE in CRT.
左心室（LV）机械性不同步是有症状心力衰竭患者更高发病率和死亡率的重要预后标志物。然而，符合当前心脏再同步治疗（CRT）指南的患者对再同步治疗的反应率各不相同。二维超声心动图和基于多普勒的技术在评估左心室不同步方面显示出不同的结果。显然需要一种能够可靠测量左心室不同步的非侵入性工具。准确预测CRT反应将改善此类治疗的患者选择。实时三维超声心动图（RT3DE）是一种新型非侵入性成像方式，最近已用于左心室整体和局部功能的定量评估。许多已发表的研究描述了RT3DE在测量左心室功能正常或降低患者的左心室不同步中的应用。源自RT3DE的收缩期不同步指数已用于量化左心室不同步，并评估和预测对CRT的反应。本综述将讨论最近发表的关于RT3DE在CRT中作用的数据。
