Lad Eleonora M, Maltenfort Mitchell G, Leng Theodore
Department of Ophthalmology, Duke Medical Center, Durham, North Carolina, USA.
Ophthalmic Surg Lasers Imaging. 2012 Mar-Apr;43(2):115-20. doi: 10.3928/15428877-20120119-01. Epub 2012 Jan 26.
To determine whether the use of lidocaine gel before application of povidone-iodine affects endophthalmitis rates following intravitreal injections.
Retrospective consecutive case series of all intravitreal injections and post-intravitreal injection endophthalmitis cases at one institution from 2000 to 2009. A review of medical records of post-intravitreal injection endophthalmitis cases was performed to determine whether lidocaine gel was applied prior to povidone-iodine antisepsis and to analyze the clinical course and outcomes.
A total of 8,802 intravitreal injections were administered during the study period. When no lidocaine gel was used prior to povidone-iodine antisepsis, four cases of endophthalmitis following 4,120 intravitreal injections (0.097%) were recorded. When 2% lidocaine gel was applied before povidone-iodine, four cases of endophthalmitis following 4,682 intravitreal injections (0.085%) were observed (P = 1.00, odds ratio = 1.12).
The use of lidocaine gel prior to povidone-iodine antisepsis did not significantly alter post-intravitreal injection endophthalmitis rates.
确定在应用聚维酮碘之前使用利多卡因凝胶是否会影响玻璃体内注射后的眼内炎发生率。
对某机构2000年至2009年期间所有玻璃体内注射及注射后发生眼内炎的病例进行回顾性连续病例系列研究。对玻璃体内注射后发生眼内炎病例的病历进行审查，以确定在聚维酮碘消毒之前是否使用了利多卡因凝胶，并分析临床病程及结果。
研究期间共进行了8802次玻璃体内注射。在聚维酮碘消毒之前未使用利多卡因凝胶时，4120次玻璃体内注射后有4例发生眼内炎（0.097%）。在聚维酮碘之前应用2%利多卡因凝胶时，4682次玻璃体内注射后观察到4例发生眼内炎（0.085%）（P = 1.00，比值比 = 1.12）。
在聚维酮碘消毒之前使用利多卡因凝胶并未显著改变玻璃体内注射后的眼内炎发生率。
