Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Ocul Pharmacol Ther. 2022 May;38(4):319-325. doi: 10.1089/jop.2021.0095. Epub 2022 Mar 7.
Intravitreal injection has become a popular treatment for various retina disorders and dramatically increased over the past few years. In traditional preintravitreal injection, the preparation steps are time consuming for practitioners who perform a significant number of injections per day. Besides, lidocaine gel (L-Gel) shows a potential absorption barrier on the antibacterial effect of povidone iodine (PI). In this study, we describe a L/PI gel system as an alternative approach to address these issues for traditional preinjection drug administration. Lidocaine and PI are loaded in a thermoresponsive gel instilled as a liquid to the lower fornix that transitions to a stable, solid gel depot. The gel demonstrated decrease in conjunctival touch sensitivity and sufficient bacteria killing with a single step, suggesting a significant decrease in the time required and less potential for drug inhibition due to sequential administration.
玻璃体腔内注射已成为治疗各种视网膜疾病的一种流行方法，在过去几年中大幅增加。在传统的玻璃体腔注射前，对于每天进行大量注射的医生来说，准备步骤非常耗时。此外，利多卡因凝胶 (L-Gel) 对聚维酮碘 (PI) 的抗菌效果表现出潜在的吸收屏障。在这项研究中，我们描述了一种 L/PI 凝胶系统，作为解决传统注射前药物给药的替代方法。利多卡因和 PI 装载在温敏凝胶中，作为液体注入下穹窿，然后转变为稳定的固体凝胶库。该凝胶可降低结膜触敏性，并可单次杀灭足够的细菌，这表明所需时间显著减少，由于顺序给药，药物抑制的可能性降低。
