Key Laboratory of Organofluorine Chfigemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
J Org Chem. 2012 Feb 17;77(4):1798-804. doi: 10.1021/jo2023262. Epub 2012 Feb 8.
A selective palladium-catalyzed Suzuki-Miyaura coupling reaction of polyfluorophenyl oxazolines through ortho C-F activation is described. It was found that reactions with DPPF as the ligand occurred much faster than those with other ligands. A variety of arylboronic acids including challenging functionalized arylboronic acids such as enolizable ketones, aldehyde, cyano, ester, and trifluoromethyl groups were tolerated with the reaction conditions.
通过邻位 C-F 活化，描述了一种对多氟苯基恶唑啉的选择性钯催化的 Suzuki-Miyaura 偶联反应。研究发现，使用 DPPF 作为配体的反应比使用其他配体的反应快得多。反应条件对各种芳基硼酸，包括具有挑战性的官能化芳基硼酸，如烯醇化酮、醛、氰基、酯和三氟甲基基团，都具有兼容性。
