Unité de recherche Génétique Cardiovasculaire EA 4373, Université de Lorraine, Faculté de Pharmacie, Nancy, France.
Metab Syndr Relat Disord. 2012 Jun;10(3):181-8. doi: 10.1089/met.2011.0097. Epub 2012 Jan 27.
The aim of this study was to investigate the difference in the prevalence of metabolic syndrome and its components between an Iranian and a French population.
The prevalence of metabolic syndrome, defined according to the Adult Treatment Panel III (ATP III), and of related abnormalities, was estimated in 1,386 French and 1,194 Iranian adults.
The prevalence of metabolic syndrome was significantly higher in Iranian women (55.0%), followed by Iranian men (30.1%), than in French men (13.7%) and French women (6.6%). Iranian women were characterized by high rates of abdominal obesity (65.0%), hypertension (52.1%), hypertriglyceridemia (43.1%), and low high-density lipoprotein cholesterol (HDL-C; 92.7%). Iranian men were characterized by high rates of hypertension (48.9%), hypertriglyceridemia (42.8%), and low HDL-C (81.8%). French men had high rates of hypertension (44.7%) and mild rates of hypertriglyceridemia (28.6%) and hyperglycemia (23.9%). There was a relationship between waist circumference and the lipid components of metabolic syndrome in both countries.
The main finding of this study is the high prevalence of low HDL-C concentrations in the Iranian population, especially in Iranian women, compared with French women. Explanation of this observation could help in establishing prevention strategies.
本研究旨在比较伊朗和法国人群中代谢综合征及其组分的患病率差异。
根据美国成人治疗小组 III 标准（ATP III），估计了 1386 名法国人和 1194 名伊朗成年人中代谢综合征及相关异常的患病率。
伊朗女性（55.0%）和男性（30.1%）的代谢综合征患病率显著高于法国女性（6.6%）和男性（13.7%）。伊朗女性具有较高的腹型肥胖（65.0%）、高血压（52.1%）、高三酰甘油血症（43.1%）和低高密度脂蛋白胆固醇（HDL-C；92.7%）发生率。伊朗男性具有较高的高血压（48.9%）、高三酰甘油血症（42.8%）和低 HDL-C（81.8%）发生率。法国男性具有较高的高血压（44.7%）和轻度高三酰甘油血症（28.6%）和高血糖（23.9%）发生率。两国人群中腰围与代谢综合征的血脂成分之间均存在相关性。
本研究的主要发现是与法国女性相比，伊朗人群，尤其是伊朗女性中低 HDL-C 浓度的患病率较高。对此观察结果的解释有助于制定预防策略。
