Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA.
Curr Drug Deliv. 2012 Mar;9(2):148-63. doi: 10.2174/156720112800234602.
In the field of pharmaceutical science and drug development, there are important and particular challenges related to the selection of suitable and compatible ingredients as well as the design of successful formulations. As plasticization is a phenomenon widely exploited in all formulation fields, plasticizers should be recognized as a critical aspect for drug delivery. The choice of an appropriate plasticizer requires a wide background of information. This is because they are incorporated into drug delivery systems containing an assortment of ingredients which may have different reactions to the presence of plasticizers. Concurrently, there are numerous pharmaceutical plasticizers and various environmental issues dictating favored solutions. To address these encumbrances, an extensive information concerning plasticizers; their types, properties, pharmaceutical roles, etc. is discussed. Additionally, the specific objective of this review is to substantiate the safety and performance of newly discovered plasticizers.
在药物科学和药物开发领域，选择合适和兼容的成分以及设计成功的配方存在着重要而特殊的挑战。由于增塑是在所有制剂领域广泛利用的现象，因此增塑剂应被视为药物传递的关键方面。选择合适的增塑剂需要广泛的信息背景。这是因为它们被掺入含有各种成分的药物输送系统中，这些成分可能对增塑剂的存在有不同的反应。同时，有许多医药用增塑剂和各种环境问题决定了优选的解决方案。为了解决这些困难，本文讨论了有关增塑剂的广泛信息；它们的类型、性质、药物作用等。此外，本综述的具体目的是证实新发现的增塑剂的安全性和性能。
