安哥拉罗安达，结核病例接触者的筛查和随访。

Screening and follow-up of children exposed to tuberculosis cases, Luanda, Angola.

机构信息

Department of Infectious Diseases, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Int J Tuberc Lung Dis. 2011 Oct;15(10):1359-61. doi: 10.5588/ijtld.11.0092.

DOI:10.5588/ijtld.11.0092

Abstract

This prospective study enrolled children aged < 5 years with reported contact with adult tuberculosis (TB) patients in Angola. The study sample consisted of 124 children: 70 (56.5%) were active TB cases, 22 (17.7%) had latent TB infection (LTBI) and 32 (25.8%) were TB-exposed; 14 (20%) were human immunodeficiency virus positive. After 6 months of follow-up, 31.8% of the LTBI cases had evolved to active TB and 9.4% of the non-infected children had developed active TB. The strategy of simultaneous chest X-ray and TB skin test used in this study was effective; despite this protocol, however, 31.8% LTBI children developed active TB.

摘要

本前瞻性研究纳入了安哥拉报告与成人肺结核（TB）患者接触的 < 5 岁儿童。研究样本包括 124 名儿童：70 名（56.5%）为活动性结核病病例，22 名（17.7%）为潜伏性结核感染（LTBI），32 名（25.8%）为结核暴露；14 名（20%）为人类免疫缺陷病毒阳性。随访 6 个月后，31.8%的 LTBI 病例发展为活动性 TB，9.4%的未感染儿童发展为活动性 TB。本研究中同时使用胸部 X 光和结核菌素皮肤试验的策略是有效的；然而，尽管采用了该方案，仍有 31.8%的 LTBI 儿童发展为活动性 TB。