Partners In Health, Boston, Massachusetts, USA.
Int J Tuberc Lung Dis. 2011 Oct;15(10):1373-9. doi: 10.5588/ijtld.10.0531.
A novel patient-centered tuberculosis (TB) treatment delivery program, 'Sputnik', was introduced for patients at high risk of treatment default in Tomsk City, Russian Federation.
To assess the effects of the Sputnik intervention on patient default rates.
We analyzed the characteristics of patients referred to the program, treatment adherence of Sputnik program enrollees before and during the intervention, and final outcomes for all patients referred to the Sputnik program.
For patients continuing their existing regimens after referral to the program (n = 46), mean adherence to treatment increased by 56% (from 52% of prescribed doses prior to enrolment to 81%). For patients initiating new regimens after referral ( n = 5), mean adherence was 83%. Mean adherence for patients with multidrug-resistant TB (MDR-TB; n = 38) was 79% and for all others (n = 13) it was 89%. The cure rate was 71.1% for patients with MDR-TB, 60% for all others and 68% in the program overall.
The Sputnik intervention was successful in reducing rates of treatment default among patients at high risk for non-adherence.
一种新的以患者为中心的结核病（TB）治疗模式“斯普特尼克”（Sputnik）在俄罗斯联邦托木斯克市推出，旨在为有较高治疗中断风险的患者提供服务。
评估 Sputnik 干预措施对患者中断率的影响。
我们分析了转诊至该项目患者的特征、Sputnik 项目参与者在干预前后的治疗依从性，以及所有转诊至 Sputnik 项目患者的最终结局。
对于转诊后继续原有方案的患者（n = 46），治疗依从性平均提高了 56%（从入组前规定剂量的 52%提高至 81%）。对于转诊后开始新方案的患者（n = 5），平均依从性为 83%。耐多药结核病（MDR-TB；n = 38）患者的平均依从性为 79%，其他患者（n = 13）的平均依从性为 89%。MDR-TB 患者的治愈率为 71.1%，其他患者为 60%，该项目总体治愈率为 68%。
Sputnik 干预措施成功降低了高失访风险患者的治疗中断率。
