Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Psychiatry Res. 2012 Jan 30;201(1):10-6. doi: 10.1016/j.pscychresns.2011.04.004. Epub 2012 Jan 28.
Previous studies suggest that baseline differences in neuronal markers between patients with obsessive-compulsive disorder (OCD) and healthy controls no longer exist following successful pharmacotherapy. The current study used proton magnetic resonance spectroscopy (MRS) to investigate differences in absolute concentrations of neurochemicals (i.e., N-acetyl-l-aspartic; NAA) in the head of the caudate nucleus (HOC) and orbital frontal white matter (OFWM) between 15 adults with OCD and a sex- and age-matched control group, as well as the effects of behavior therapy on these chemicals. Behavior therapy was associated with a significant increase in left HOC NAA. When the analyses were restricted to only pairings with complete data (OCD patient, control, post-treatment), the levels of left HOC NAA were significantly lower in patients compared to controls, and increased significantly with treatment. Exploratory analyses suggested that levels of NAA and Cr (creatine) in the right OFWM may be significantly lower in the OCD group than the control group. The results raise the possibility that successful behavioral treatment may be associated with increases in markers of neuronal viability, although other associations found in the literature were not replicated.
先前的研究表明，在强迫症（OCD）患者成功接受药物治疗后，其神经元标志物与健康对照组之间的基线差异不再存在。本研究使用质子磁共振波谱（MRS）技术，来研究 15 名 OCD 成年患者与性别和年龄匹配的对照组之间，尾状核头部（HOC）和眶额白质（OFWM）中神经化学物质（即 N-乙酰-l-天冬氨酸；NAA）的绝对浓度的差异，以及行为疗法对这些化学物质的影响。行为疗法与左侧 HOC NAA 的显著增加有关。当分析仅限于具有完整数据的配对（OCD 患者、对照、治疗后）时，患者的左侧 HOC NAA 水平明显低于对照组，并且随着治疗显著增加。探索性分析表明，OCD 组右 OFWM 中的 NAA 和 Cr（肌酸）水平可能明显低于对照组。这些结果表明，成功的行为治疗可能与神经元生存能力标志物的增加有关，尽管文献中发现的其他关联并未得到复制。
