Ariel University Center of Samaria, Ariel, Israel.
Brain Res. 2012 Mar 14;1443:89-97. doi: 10.1016/j.brainres.2012.01.001. Epub 2012 Jan 9.
The resin of Boswellia species is a major anti-inflammatory agent that has been used for centuries to treat various conditions including injuries and inflammatory conditions. Incensole acetate (IA), a major constituent of this resin, has been shown to inhibit NF-κB activation and concomitant inflammation, as well as the neurological deficit following head trauma. Here, we show that IA protects against ischemic neuronal damage and reperfusion injury in mice, attenuating the inflammatory nature of ischemic damage. IA given post-ischemia, reduced infarct volumes and improved neurological activities in the mouse model of ischemic injury in a dose dependent fashion. The protection from damage was accompanied by inhibition of TNF-α, IL-1β and TGF-β expression, as well as NF-κB activation following injury. In addition, IA is shown to have a therapeutic window of treatment up to 6h after ischemic injury. Finally, the protective effects of IA were partially mediated by TRPV3 channels as determined by the TRPV3 deficient mice and channel blocker studies. This study suggests that the anti-inflammatory and neuroprotective activities of IA may serve as a novel therapeutic treatment for ischemic and reperfusion injury, and as a tool in the ongoing research of mechanisms for neurological damage.
乳香树树脂是一种主要的抗炎剂，几个世纪以来一直被用于治疗各种疾病，包括外伤和炎症。乳香酸（IA），是这种树脂的主要成分之一，已被证明可以抑制 NF-κB 的激活和随之而来的炎症，以及头部创伤后的神经功能缺损。在这里，我们表明 IA 可以防止小鼠的缺血性神经元损伤和再灌注损伤，减轻缺血性损伤的炎症性质。IA 在缺血性损伤的小鼠模型中，以剂量依赖的方式，减少梗死体积并改善神经功能活动。损伤后，IA 还抑制 TNF-α、IL-1β 和 TGF-β 的表达以及 NF-κB 的激活，从而实现对损伤的保护。此外，IA 在缺血损伤后 6 小时内具有治疗窗。最后，通过 TRPV3 缺陷小鼠和通道阻滞剂研究确定，IA 的保护作用部分是由 TRPV3 通道介导的。这项研究表明，IA 的抗炎和神经保护活性可能成为缺血和再灌注损伤的一种新的治疗方法，并为神经损伤机制的持续研究提供一种工具。
