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自闭症的神经生物学基础。

Neurobiological basis of autism.

机构信息

Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Pediatr Clin North Am. 2012 Feb;59(1):45-61, x. doi: 10.1016/j.pcl.2011.10.010.

DOI:10.1016/j.pcl.2011.10.010
PMID:22284792
Abstract

Autism (autism spectrum disorders) is a complex, strongly genetically influenced, behaviorally defined disorder of the immature brain associated with very uneven intellectual abilities. Among its most salient and potentially treatable neurologic features that this article focuses on are epilepsy, disorganized sleep patterns, and sensory and motor deficits. Its many causes and wide range of severity means that there is no symptom, no pathology, imaging, electroencephalography, or other biologic feature, and no biologic treatment that is universal or diagnostic of this developmental syndrome.

摘要

自闭症(自闭症谱系障碍)是一种复杂的、受强烈遗传影响的、以行为定义的未成熟大脑障碍,与非常不均衡的智力能力有关。本文重点关注的其最显著和潜在可治疗的神经特征包括癫痫、睡眠模式紊乱、感觉和运动缺陷。其众多原因和广泛的严重程度意味着,没有一种症状、病理学、影像学、脑电图或其他生物学特征,也没有一种生物学治疗方法是普遍的或可以诊断这种发育综合征的。

相似文献

1
Neurobiological basis of autism.自闭症的神经生物学基础。
Pediatr Clin North Am. 2012 Feb;59(1):45-61, x. doi: 10.1016/j.pcl.2011.10.010.
2
Epilepsy in patients with pervasive developmental disorder not otherwise specified.未另行指定的广泛性发育障碍患者中的癫痫
J Child Neurol. 2007 Oct;22(10):1198-203. doi: 10.1177/0883073807306265.
3
Autism and epilepsy: cause, consequence, comorbidity, or coincidence?自闭症与癫痫:病因、后果、共病还是巧合?
Epilepsy Behav. 2005 Dec;7(4):652-6. doi: 10.1016/j.yebeh.2005.08.008. Epub 2005 Oct 24.
4
[Pervasive developmental disorders: neurological perspectives].[广泛性发育障碍:神经学视角]
Rev Neurol. 1996 Nov;24(135):1446-50.
5
Sleep and autism spectrum disorders.睡眠与自闭症谱系障碍。
Pediatr Clin North Am. 2011 Jun;58(3):685-98. doi: 10.1016/j.pcl.2011.03.009.
6
Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders.自闭症谱系障碍婴幼儿、儿童和成人运动功能的研究现状。
Phys Ther. 2011 Jul;91(7):1116-29. doi: 10.2522/ptj.20100294. Epub 2011 May 5.
7
[Sleep in neurodevelopmental disorders].[神经发育障碍中的睡眠]
Rev Neurol. 2009 Feb 27;48 Suppl 2:S13-6.
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Developmental profiles in preschool children with autism spectrum disorders referred for intervention.自闭症谱系障碍儿童发展特征,这些儿童已被推荐接受干预。
Res Dev Disabil. 2010 May-Jun;31(3):790-9. doi: 10.1016/j.ridd.2010.02.003. Epub 2010 Mar 5.
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Sleep problems in autism spectrum disorders: prevalence, nature, & possible biopsychosocial aetiologies.自闭症谱系障碍中的睡眠问题:患病率、性质及可能的生物心理社会病因。
Sleep Med Rev. 2009 Dec;13(6):403-11. doi: 10.1016/j.smrv.2009.02.003. Epub 2009 Apr 24.
10
Sensory processing, problem behavior, adaptive behavior, and cognition in preschool children with autism spectrum disorders.自闭症谱系障碍学龄前儿童的感觉处理、问题行为、适应行为和认知。
Am J Occup Ther. 2012 Sep-Oct;66(5):586-94. doi: 10.5014/ajot.2012.004168.

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Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations.自闭症样特质个体经 5 天磁刺激后情绪识别准确性提高。
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Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder.脂质代谢标志物受损评估自闭症谱系障碍神经炎症风险。
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INTERNEURONOPATHIES AND THEIR ROLE IN EARLY LIFE EPILEPSIES AND NEURODEVELOPMENTAL DISORDERS.中间神经元病变及其在早期生活癫痫和神经发育障碍中的作用。
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Disruption to control network function correlates with altered dynamic connectivity in the wider autism spectrum.控制网络功能的破坏与更广泛自闭症谱系中动态连接性的改变相关。
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