自闭症的神经生物学基础。

Neurobiological basis of autism.

机构信息

Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Pediatr Clin North Am. 2012 Feb;59(1):45-61, x. doi: 10.1016/j.pcl.2011.10.010.

DOI:10.1016/j.pcl.2011.10.010

Abstract

Autism (autism spectrum disorders) is a complex, strongly genetically influenced, behaviorally defined disorder of the immature brain associated with very uneven intellectual abilities. Among its most salient and potentially treatable neurologic features that this article focuses on are epilepsy, disorganized sleep patterns, and sensory and motor deficits. Its many causes and wide range of severity means that there is no symptom, no pathology, imaging, electroencephalography, or other biologic feature, and no biologic treatment that is universal or diagnostic of this developmental syndrome.

摘要

自闭症（自闭症谱系障碍）是一种复杂的、受强烈遗传影响的、以行为定义的未成熟大脑障碍，与非常不均衡的智力能力有关。本文重点关注的其最显著和潜在可治疗的神经特征包括癫痫、睡眠模式紊乱、感觉和运动缺陷。其众多原因和广泛的严重程度意味着，没有一种症状、病理学、影像学、脑电图或其他生物学特征，也没有一种生物学治疗方法是普遍的或可以诊断这种发育综合征的。