State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
J Transl Med. 2012 Jan 27;10:16. doi: 10.1186/1479-5876-10-16.
Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown.
197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the prognostic effects of vitamin D.
The mean vitamin D levels of the 197 gastric patients was 49.85 ± 23.68 nmol/L, among whom 114(57.9%) were deficient in Vitamin D(< 50 nmol/L), 67(34%) were insufficient (50-75 nmol/L) and 16(8.1%) were sufficient (> 75 nmol/L). Clinical stage (P = 0.004) and lymph node metastasis classification (P = 0.009) were inversely associated with vitamin D levels. The patients with high vitamin D levels group (≥ 50 nmol/L) had a higher overall survival compared with the low vitamin D levels group (< 50 nmol/L)(P = 0.018). Multivariate analysis indicated that vitamin D levels were an independent prognostic factor of gastric cancer (P = 0.019).
Vitamin D deficiency may be associated with poor prognosis in gastric cancer.
关于维生素 D 与胃癌之间的关联，大型流行病学研究的结果存在争议。维生素 D 可显著促进未分化胃癌细胞的凋亡，但目前尚不清楚其水平的预后影响。
本研究纳入了 197 例 2002 年 1 月至 2006 年 1 月在中山大学肿瘤中心接受治疗的胃癌患者。检测了治疗前采集的储存血液中的 25-羟维生素 D 水平。收集了临床病理数据，以检查维生素 D 的预后影响。
197 例胃癌患者的平均维生素 D 水平为 49.85±23.68nmol/L，其中 114 例（57.9%）维生素 D 缺乏（<50nmol/L），67 例（34%）不足（50-75nmol/L），16 例（8.1%）充足（>75nmol/L）。临床分期（P=0.004）和淋巴结转移分类（P=0.009）与维生素 D 水平呈负相关。维生素 D 水平较高组（≥50nmol/L）的总生存率高于维生素 D 水平较低组（<50nmol/L）（P=0.018）。多因素分析表明，维生素 D 水平是胃癌的独立预后因素（P=0.019）。
维生素 D 缺乏可能与胃癌的不良预后有关。
