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新型 2-[2-(4-氯苯基)苯并咪唑-1-基]-N-(2-芳基亚甲基氨基)乙酰胺和 2-[2-(4-氯苯基)苯并咪唑-1-基]-N-(4-氧代-2-芳基噻唑烷-3-基)乙酰胺的合成与抗氧化性能评价-I。

Synthesis and evaluation of antioxidant properties of novel 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(2-arylmethylene amino) acetamides and 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl) acetamides-I.

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Tandogan, Ankara, Turkey.

出版信息

Chem Biol Drug Des. 2012 May;79(5):869-77. doi: 10.1111/j.1747-0285.2012.01347.x. Epub 2012 Feb 23.

DOI:10.1111/j.1747-0285.2012.01347.x
PMID:22284863
Abstract

Our approach was to synthesize and examine the antioxidant properties of some new 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(2-arylmethyleneamino) acetamide (1-18) and 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl)acetamide (1t-18t) derivatives. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O-deethylase activities (EROD assay) were determined. The free radical scavenging properties of the compounds were also examined in vitro determining the interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. The compounds showed significant effects in the above tests.

摘要

我们的方法是合成并研究一些新的 2-[2-(4-氯苯基)苯并咪唑-1-基]-N-(2-芳基亚甲基氨基)乙酰胺（1-18）和 2-[2-(4-氯苯基)苯并咪唑-1-基]-N-(4-氧代-2-芳基噻唑烷-3-基)乙酰胺（1t-18t）衍生物的抗氧化性能。在体外测定它们对大鼠肝微粒体 NADPH 依赖性脂质过氧化水平（LP 测定）和微粒体乙氧基 RESORUFIN O-去乙基酶活性（EROD 测定）的影响。还通过测定 2,2-二苯基-1-苦基肼（DPPH）自由基的相互作用，在体外检查了化合物的自由基清除特性。这些化合物在上述试验中表现出显著的效果。

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