Ayhan-Kilcigil Gülgün, Kus Canan, Coban Tülay, Can-Eke Benay, Iscan Mumtaz
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara-Turkey.
J Enzyme Inhib Med Chem. 2004 Apr;19(2):129-35. doi: 10.1080/1475636042000202017.
Some novel benzimidazole derivatives carrying thiosemicarbazide and triazole moieties at the N1 position were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels determined by measuring the formation of 2-thiobarbituric acid reactive substance. The free radical scavenging properties of the compounds were also examined in vitro by determining the capacity to scavenge superoxide anion formation and the interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The compounds showed a significant effect in the above tests except to scavenge superoxide anion formation.
合成了一些在N1位带有氨基硫脲和三唑部分的新型苯并咪唑衍生物，并通过测量2-硫代巴比妥酸反应性物质的形成来测定它们对大鼠肝微粒体NADPH依赖性脂质过氧化（LP）水平的体外影响。还通过测定清除超氧阴离子形成的能力以及与稳定自由基2,2-二苯基-1-苦基肼（DPPH）的相互作用，在体外检测了这些化合物的自由基清除特性。除了清除超氧阴离子形成外，这些化合物在上述测试中显示出显著效果。
