Fourth Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.
Am J Obstet Gynecol. 2012 Apr;206(4):337.e1-5. doi: 10.1016/j.ajog.2011.12.024. Epub 2011 Dec 27.
To systematically review published data on the neurodevelopment of children that were diagnosed prenatally with isolated agenesis of the corpus callosum.
Medline and Scopus searches (1960-July 2011); cross-referencing of retrieved articles.
Sixteen reports (132 cases of apparently isolated agenesis of the corpus callosum) were included in the analysis. The rates of normal outcome, borderline or moderate disability and severe disability were 94/132 (71.2%; 95% confidence interval [CI], 63.0-78.3), 18/132 (13.6%; 95% CI, 8.8-20.5), and 22/132 (15.2%; 95% CI, 10.0-22.2), respectively. Magnetic resonance imaging detected additional cerebral abnormalities in 22.5% (95% CI, 12.3-37.5) of apparently isolated agenesis of the corpus callosum cases. In truly isolated agenesis of the corpus callosum (confirmed by magnetic resonance imaging), the rates of normal neurodevelopment and severe disability were 52/69 (75.4%; 95% CI, 64.0-84.0) and 8/69 (11.6%; 95% CI, 6.0-21.2), respectively.
Prenatally diagnosed, isolated agenesis of the corpus callosum is usually associated with a favorable outcome. Larger, prospective series are required, as current data are limited, inconsistent, and prevent subgroup analyses (eg, complete vs partial agenesis of the corpus callosum).
系统回顾发表的关于产前诊断为单纯胼胝体发育不全的儿童神经发育的研究数据。
在 Medline 和 Scopus 上进行检索（1960 年至 2011 年 7 月）；检索文章的交叉参考。
纳入分析的有 16 份报告（132 例单纯胼胝体发育不全）。正常结局、临界或中度残疾和严重残疾的发生率分别为 94/132（71.2%；95%可信区间[CI]，63.0-78.3）、18/132（13.6%；95% CI，8.8-20.5）和 22/132（15.2%；95% CI，10.0-22.2）。磁共振成像（MRI）在 22.5%（95% CI，12.3-37.5）的单纯胼胝体发育不全病例中检测到其他脑异常。在真正的单纯胼胝体发育不全（MRI 证实）中，正常神经发育和严重残疾的发生率分别为 52/69（75.4%；95% CI，64.0-84.0）和 8/69（11.6%；95% CI，6.0-21.2）。
产前诊断为单纯胼胝体发育不全通常与良好的结局相关。需要更大的、前瞻性的系列研究，因为目前的数据有限、不一致，且无法进行亚组分析（如完全性与部分性胼胝体发育不全）。
