Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Am J Obstet Gynecol. 2012 Mar;206(3):218.e1-13. doi: 10.1016/j.ajog.2011.12.018. Epub 2011 Dec 27.
The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid.
The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid.
The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid.
The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus.
本研究旨在探讨糖尿病与围孕期未使用含有叶酸的复合维生素或补充剂与出生缺陷风险的关系。
全国出生缺陷预防研究(1997-2004 年)是一项多中心、基于人群的出生缺陷病例对照研究(14721 例病例和 5437 例对照婴儿)。病例分为 18 种类型的心脏缺陷和 26 种非心脏出生缺陷。我们估计了糖尿病的预先存在和缺乏围孕期使用含有叶酸的维生素或补充剂的独立和联合作用的比值比。
比值比的模式表明,在缺乏 vs 存在围孕期使用含有叶酸的维生素或补充剂的情况下,与糖尿病相关的缺陷风险增加。
缺乏围孕期使用含有叶酸的维生素或补充剂可能与由于糖尿病引起的出生缺陷风险增加有关。