Department of Cardiology, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, SA 5011, Australia.
Heart Lung Circ. 2012 Apr;21(4):203-5. doi: 10.1016/j.hlc.2011.12.004. Epub 2012 Jan 27.
Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being precipitated in many cases by severe emotional stress. We describe six patients in whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/noradrenaline reuptake inhibitor venlafaxine, or its metabolite desvenlafaxine. Importantly, two of the six cases were not post-menopausal women. An increased risk of TTC may account for some of the reported cardiovascular adverse effects of venlafaxine and similar agents.
心尖球形综合征（TTC）特别发生于绝经后女性，在许多情况下由严重的情绪压力引发。我们描述了 6 例因服用或过量服用 5-羟色胺/去甲肾上腺素再摄取抑制剂文拉法辛或其代谢物去甲文拉法辛而发生 TTC 的患者。重要的是，这 6 例中有 2 例并非绝经后女性。TTC 的风险增加可能是文拉法辛和类似药物报告的一些心血管不良事件的原因之一。
