Yalta Kenan, Palabıyık Orkide, Gurdogan Muhammet, Yetkın Ertan
Cardiology Department, School of Medicine, TrakyaUniversity, Balkan Yerleşkesi, 22030, Edirne, Turkey.
Trakya University, Vocational Collage of Health Services, Edirne, Turkey.
Heart Fail Rev. 2024 Jan;29(1):27-44. doi: 10.1007/s10741-023-10344-z. Epub 2023 Sep 12.
Hyponatremia is a common electrolyte abnormality with important prognostic and therapeutic implications. It might exert detrimental effects on various organ systems including the central nervous system (CNS), bone, and heart along with its potential association with poor quality of life. These adverse effects might be largely mediated through a variety of mechanisms including osmotic stress, dysfunctional transmembrane exchangers, and enhanced oxidative stress.Interestingly, hyponatremia might also have an important association with takotsubo syndrome (TTS) that has been universally considered as a reversible form of cardiomyopathy usually emerging in response to various stressors. In this context, severe hyponatremia was previously reported to serve as a direct trigger of TTS evolution largely through its potential impact on CNS and heart. However, pathogenetic and clinical implications of hyponatremia still need to be thoroughly evaluated in patients with TTS. This paper aims to analyze the clinical features of published cases with TTS primarily triggered by hyponatremia and also aims to discuss the association between hyponatremia and TTS from a broader perspective.
低钠血症是一种常见的电解质异常，具有重要的预后和治疗意义。它可能会对包括中枢神经系统（CNS）、骨骼和心脏在内的各种器官系统产生有害影响，并可能与生活质量差相关。这些不良反应可能主要通过多种机制介导，包括渗透压应激、功能失调的跨膜交换器和氧化应激增强。有趣的是，低钠血症可能还与应激性心肌病（TTS）有重要关联，TTS通常被认为是一种可逆的心肌病形式，通常在应对各种应激源时出现。在这种情况下，先前有报道称，严重低钠血症主要通过其对中枢神经系统和心脏的潜在影响，直接引发TTS的进展。然而，低钠血症在TTS患者中的发病机制和临床意义仍需全面评估。本文旨在分析主要由低钠血症引发的TTS已发表病例的临床特征，并从更广泛的角度探讨低钠血症与TTS之间的关联。
