特发性 REM 睡眠行为障碍中的决策障碍。
Impaired decision-making in idiopathic REM sleep behavior disorder.
机构信息
Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
出版信息
Sleep Med. 2012 Mar;13(3):301-6. doi: 10.1016/j.sleep.2011.09.012. Epub 2012 Jan 30.
BACKGROUND
Patients with REM sleep behavior disorder (RBD) frequently develop Parkinson's disease (PD), which can impair decision-making ability. This study was undertaken to investigate decision-making ability and its relation to olfactory function in patients with idiopathic RBD.
METHODS
This study used the Iowa Gambling Task (IGT) and the Sniffin' Stick Test for examination of 38 patients with idiopathic RBD (iRBD) and 34 age-matched healthy control subjects (HC). Associations between these test results and other clinical RBD variables were also assessed.
RESULTS
Total IGT score and Sniffin' Stick Test scores were significantly lower in the iRBD group than in the HC group. The iRBD group IGT scores in the first, third, and final blocks were significantly lower than those of the HC group. In the iRBD group, no association was found between the total IGT score and the Sniffin' Stick Test score or any clinical RBD variable.
CONCLUSIONS
Impaired decision-making associated with iRBD can herald PD. However, decision-making disability is thought to appear irrespective of olfactory dysfunction and progression of RBD pathology.
背景
快速眼动睡眠行为障碍（RBD）患者常发展为帕金森病（PD），这可能会损害决策能力。本研究旨在探讨特发性 RBD 患者的决策能力及其与嗅觉功能的关系。
方法
本研究使用了 Iowa 赌博任务（IGT）和 Sniffin' Stick 测试来检查 38 名特发性 RBD（iRBD）患者和 34 名年龄匹配的健康对照组（HC）。还评估了这些测试结果与其他临床 RBD 变量之间的关联。
结果
iRBD 组的总 IGT 评分和 Sniffin' Stick 测试评分明显低于 HC 组。iRBD 组在第一、第三和最后几轮的 IGT 评分明显低于 HC 组。在 iRBD 组中，总 IGT 评分与 Sniffin' Stick 测试评分或任何临床 RBD 变量之间均无关联。
结论
与 iRBD 相关的决策受损可能预示着 PD。然而，据认为，决策障碍的出现与嗅觉功能障碍和 RBD 病理进展无关。
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