Herd M Kerry, Murugaraj Vaidayanathan, Ghataura Sukhvinder Singh, Brennan Peter A, Anand Rajiv
Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
J Oral Maxillofac Surg. 2012 Oct;70(10):2343-6. doi: 10.1016/j.joms.2011.11.019. Epub 2012 Jan 28.
Intraoral low-grade mucoepidermoid carcinoma (MEC) is not known to metastasize to the liver. This type of malignant salivary gland tumor is comparatively rare and has a well-defined set of parameters guiding histolopathologic grading into low to high grade. Although distant and regional lymph node metastases have been reported in about 15% of all MEC cases, tumors diagnosed as low grade have only very rarely been implicated. We present a case, as yet unreported, in which cervical lymph node and hepatic metastatic spread occurred from a primary low-grade MEC of the hard palate. A 33-year-old man presented with a 4-week history of painful, right-sided palatal ulceration crossing the midline. Imaging revealed cervical lymph node involvement and metastatic liver deposits. Tissue diagnosis supported a low-grade palatal MEC with histologic identical hepatic metastases. We examined the clinical features of this rare case, reviewed the published data, and discuss the histologic features and treatment of such patients.
口腔内低级别黏液表皮样癌（MEC）尚无转移至肝脏的报道。这种类型的恶性唾液腺肿瘤相对罕见，有一套明确的参数用于指导组织病理学分级，从低级别到高级别。虽然在所有MEC病例中约15%报告有远处和区域淋巴结转移，但诊断为低级别肿瘤的情况极为罕见。我们报告一例尚未见报道的病例，其中一名33岁男性患者，硬腭原发性低级别MEC发生了颈部淋巴结和肝脏转移。该患者有右侧腭部疼痛性溃疡4周病史，溃疡越过中线。影像学检查显示颈部淋巴结受累及肝脏转移灶。组织诊断支持低级别腭部MEC伴组织学上相同的肝脏转移。我们检查了这一罕见病例的临床特征，回顾了已发表的数据，并讨论了此类患者的组织学特征和治疗方法。
