CC 趋化因子受体-2（CCR2）和 -5（CCR5）基因多态性与突尼斯男性患者心肌梗死风险的相关性。

Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of myocardial infarction among Tunisian male patients.

机构信息

LR99ES11, Research Laboratory, Department of Biochemistry, Rabta Hospital, Tunis, Tunisia.

出版信息

Clin Biochem. 2012 Apr;45(6):420-4. doi: 10.1016/j.clinbiochem.2012.01.004. Epub 2012 Jan 20.

DOI:10.1016/j.clinbiochem.2012.01.004

PMID:22285384

Abstract

OBJECTIVES

The aim of the present study was to investigate the association between CCR2-Val64Ile and CCR5-Δ32 variants and the estimation of haplotypes with MI in a sample of the Tunisian population.

DESIGN AND METHODS

A total of 290 unrelated MI patients and 282 healthy controls were studied. The CCR2-Val64Ile and CCR5-Δ32 variants were analyzed by PCR-RFLP.

RESULTS

Subjects carrying at least one copy of the CCR5-deletion allele were significantly more common in the control group, suggesting an atheroprotective effect (adjusted OR=0.44, 95% CI=0.28-0.72, p=0.001). Haplotype analysis showed that MI patients had significantly less 64Val-Del haplotype (9.9% vs. 21.3%, OR=0.30, 95% CI=0.21-0.43, p<0.001) and 64Ile-Ins haplotype (12.3% vs. 16.7%, OR=0.58, 95% CI=0.42-0.80, p<0.001).

CONCLUSION

A protective effect of the CCR5-Δ32 polymorphism against MI in the Tunisian population was found.

摘要

目的

本研究旨在探讨 CCR2-Val64Ile 和 CCR5-Δ32 变体与心肌梗死（MI）在突尼斯人群中的关联，并对单倍型进行估计。

设计和方法

共研究了 290 例无关的 MI 患者和 282 例健康对照者。采用 PCR-RFLP 分析 CCR2-Val64Ile 和 CCR5-Δ32 变体。

结果

携带至少一个 CCR5 缺失等位基因的受试者在对照组中更为常见，提示具有抗动脉粥样硬化作用（校正 OR=0.44，95%CI=0.28-0.72，p=0.001）。单倍型分析显示，MI 患者的 64Val-Del 单倍型（9.9%对 21.3%，OR=0.30，95%CI=0.21-0.43，p<0.001）和 64Ile-Ins 单倍型（12.3%对 16.7%，OR=0.58，95%CI=0.42-0.80，p<0.001）明显减少。