下一代测序方法在复杂疾病遗传图谱构建中的应用。

Next-generation sequencing approaches for genetic mapping of complex diseases.

机构信息

Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.

出版信息

J Neuroimmunol. 2012 Jul 15;248(1-2):10-22. doi: 10.1016/j.jneuroim.2011.12.017. Epub 2012 Jan 27.

DOI:10.1016/j.jneuroim.2011.12.017

PMID:22285396

Abstract

The advent of next generation sequencing technologies has opened new possibilities in the analysis of human disease. In this review we present the main next-generation sequencing technologies, with their major contributions and possible applications to the study of the genetic etiology of complex diseases.

摘要

下一代测序技术的出现为人类疾病的分析开辟了新的可能性。在这篇综述中，我们介绍了主要的下一代测序技术，及其在复杂疾病的遗传病因研究中的主要贡献和可能的应用。