Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA.
Leuk Res. 2012 Jul;36(7):868-75. doi: 10.1016/j.leukres.2011.12.020. Epub 2012 Jan 29.
The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associated with a relative risk (RR) of 1.26 (95% CI 1.17-1.37; p < 0.001) for leukemia incidence and 1.29 (95% CI 1.11-1.49; p = 0.001) for mortality. Obesity was also associated with an increased incidence of acute myeloid leukemia (RR 1.53, 95% CI 1.26-1.85; p<0.001), chronic lymphocytic leukemia (RR 1.17, 95% CI 1.08-1.27; p < 0.001), chronic myeloid leukemia (RR 1.16, 95% CI 1.04-1.30; p = 0.007) and acute lymphoblastic leukemia (RR 1.62, 95% CI 1.12-2.32; p = 0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men.
本前瞻性队列研究荟萃分析的主要目的是评估肥胖对成年人白血病发病和死亡的影响。肥胖与白血病发病的相对风险（RR）为 1.26（95%CI 1.17-1.37；p<0.001），与死亡率的 RR 为 1.29（95%CI 1.11-1.49；p=0.001）。肥胖也与急性髓系白血病（RR 1.53，95%CI 1.26-1.85；p<0.001）、慢性淋巴细胞白血病（RR 1.17，95%CI 1.08-1.27；p<0.001）、慢性髓系白血病（RR 1.16，95%CI 1.04-1.30；p=0.007）和急性淋巴细胞白血病（RR 1.62，95%CI 1.12-2.32；p=0.009）的发病风险增加相关。肥胖男性白血病发病和死亡的风险始终更高。
