Herman B Wells Center for Pediatric Research, Department of Pediatrics.
Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Curr Opin Hematol. 2024 Jul 1;31(4):193-198. doi: 10.1097/MOH.0000000000000819. Epub 2024 Apr 19.
This review meticulously delves into existing literature and recent findings to elucidate the intricate link between obesity and clonal hematopoiesis of indeterminate potential (CHIP) associated clonal hematopoiesis. It aims to enhance our comprehension of this multifaceted association, offering insights into potential avenues for future research and therapeutic interventions.
Recent insights reveal that mutations in CHIP-associated genes are not limited to symptomatic patients but are also present in asymptomatic individuals. This section focuses on the impact of obesity-induced inflammation and fatty bone marrow (FBM) on the development of CHIP-associated diseases. Common comorbidities such as obesity, diabetes, and infection, fostering pro-inflammatory environments, play a pivotal role in the acceleration of these pathologies. Our research underscores a notable association between CHIP and an increased waist-to-hip ratio (WHR), emphasizing the link between obesity and myeloid leukemia. Recent studies highlight a strong correlation between obesity and myeloid leukemias in both children and adults, with increased risks and poorer survival outcomes in overweight individuals.
We discuss recent insights into how CHIP-associated pathologies respond to obesity-induced inflammation, offering implications for future studies in the intricate field of clonal hematopoiesis.
本综述深入探讨了现有的文献和最新发现，阐明了肥胖症与不确定潜能的克隆性造血（CHIP）相关克隆性造血之间的复杂联系。旨在增进我们对这一多方面关联的理解，为未来的研究和治疗干预提供思路。
最近的研究结果表明，CHIP 相关基因的突变不仅局限于有症状的患者，也存在于无症状个体中。本节重点讨论肥胖引起的炎症和脂肪性骨髓（FBM）对 CHIP 相关疾病发展的影响。肥胖症、糖尿病和感染等常见合并症会形成促炎环境，在这些病理的加速发展中起着关键作用。我们的研究强调了 CHIP 与腰围臀围比（WHR）增加之间的显著关联，突出了肥胖症与骨髓性白血病之间的联系。最近的研究强调了肥胖症与儿童和成人骨髓性白血病之间的强烈相关性，超重个体的风险增加和生存预后较差。
我们讨论了最近关于 CHIP 相关病理如何对肥胖引起的炎症作出反应的研究结果，为克隆性造血这一复杂领域的未来研究提供了启示。
