URESP, Centre de recherche FRSQ du CHA universitaire de Québec, QC, Canada.
Vaccine. 2012 Mar 9;30(12):2047-50. doi: 10.1016/j.vaccine.2012.01.045. Epub 2012 Jan 28.
We conducted a prospective multi-center study to assess productivity loss associated with herpes zoster (HZ) and postherpetic neuralgia (PHN). From 10/2005 to 07/2006, we recruited immunocompetent subjects aged ≥50 years with HZ within 14 days of rash onset across Canada. Of the 249 patients recruited, 88 were employed. Data on employment status, absences from work, reasons for absence and effectiveness at work were documented at recruitment, 7-14-21-30-60-90-120-150 and 180 days later. The majority (64%) of employed subjects missed work because of HZ and 76% reported decreased effectiveness at work (i.e. presenteeism) because of HZ/PHN. Mean hours of absenteeism and presenteeism per working individual were 27 and 34 h, respectively. Pain severity and duration were associated with greater productivity loss. These results provide new information about the burden of HZ and PHN, which is useful for public health planning and cost-effectiveness analyses of HZ vaccination among individuals of working age.
我们开展了一项前瞻性多中心研究，评估带状疱疹（HZ）和带状疱疹后神经痛（PHN）相关的生产力损失。2005 年 10 月至 2006 年 7 月，我们在加拿大各地招募了年龄≥50 岁、皮疹发病后 14 天内患有 HZ 的免疫功能正常的受试者。在招募的 249 名患者中，有 88 人就业。在招募时以及随后的第 7、14、21、30、60、90、120、150 和 180 天，记录了就业状况、缺勤、缺勤原因和工作效率。大多数（64%）就业的受试者因 HZ 而缺勤，76%的人报告因 HZ/PHN 而工作效率下降（即出勤）。每个劳动者的平均缺勤和出勤时间分别为 27 小时和 34 小时。疼痛严重程度和持续时间与生产力损失的增加有关。这些结果提供了有关 HZ 和 PHN 负担的新信息，这对于公共卫生规划和对工作年龄个体进行 HZ 疫苗接种的成本效益分析很有用。
