红斑狼疮合并带状疱疹：患病率、发病率及危险因素。
Herpes zoster in SLE: prevalence, incidence and risk factors.
机构信息
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Medicine, Prince Sultan Military Medical City, Riyadh, Riyadh, Saudi Arabia.
出版信息
Lupus Sci Med. 2022 Jan;9(1). doi: 10.1136/lupus-2021-000574.
OBJECTIVES
This study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.
METHODS
491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.
RESULTS
Prevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.
CONCLUSIONS
HZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.
目的
本研究旨在评估系统性红斑狼疮（SLE）患者中带状疱疹（HZ）事件的患病率和发生率，并描述其相关因素。
方法
对 491 例连续的 SLE 患者进行 HZ 事件筛查，采用患者报告问卷来获取与 HZ 事件相关的疼痛和其他特征的结局。同时分析了社会人口统计学、临床和实验室指标，并进行了时间依赖性 Cox 回归生存分析，以调查与 HZ 事件相关的因素。
结果
HZ 的患病率为 30.5%，发病率为每 1000 人年 14.3 例。淋巴细胞减少症和糖皮质激素剂量与 HZ 事件显著相关。
结论
HZ 在 SLE 中发病率很高，这可能与疾病相关和治疗相关的细胞免疫功能下降有关。我们的研究结果表明，存在某些危险因素可能有助于识别 HZ 风险患者，并改善 SLE 患者的 HZ 管理。
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