免疫功能正常患者的上颌窦侵袭性曲霉病
[Invasive aspergillosis of the maxillary sinus in an immunocompetent patient].
作者信息
Abir B, Abouchadi A, Hamama J, Oukabli M, Nassih M, Rzin A
机构信息
Service de chirurgie plastique et stomatologie, hôpital militaire d'instruction Mohamed-V, Rabat, Maroc.
出版信息
Rev Stomatol Chir Maxillofac. 2012 Apr;113(2):127-30. doi: 10.1016/j.stomax.2011.12.011. Epub 2012 Jan 28.
INTRODUCTION
Invasive aspergillosis of the maxillary sinus is a severe infection most commonly observed in immunocompromised patients. We report a pseudo-tumoral presentation of invasive aspergillosis of the maxillary sinus, in immunocompetent adult.
CASE REPORT
A 70-year-old female patient consulted for chronic rhino-sinusitis resistant to medical treatment. Computed tomography scan revealed a hyperdense mass filling the left maxillary antrum, with erosion of sinus walls. The ethmoidal and right frontal sinuses were involved. The histological and mycological examination of the surgical resection confirmed the diagnosis of invasive aspergillosis. The patient was given voriconazole as first line treatment. The outcome was good at 18 months.
DISCUSSION
Invasive aspergillosis of the maxillary sinus is a rare disease, usually observed in immunodepressed patients. It is very rarely observed in immunocompetent patients.
引言
上颌窦侵袭性曲霉病是一种严重感染，最常见于免疫功能低下的患者。我们报告了一例免疫功能正常的成年人上颌窦侵袭性曲霉病的假瘤样表现。
病例报告
一名70岁女性患者因药物治疗无效的慢性鼻窦炎前来就诊。计算机断层扫描显示一个高密度肿块充满左上颌窦，并伴有窦壁侵蚀。筛窦和右侧额窦也受累。手术切除标本的组织学和真菌学检查确诊为侵袭性曲霉病。患者接受伏立康唑作为一线治疗。18个月时预后良好。
讨论
上颌窦侵袭性曲霉病是一种罕见疾病，通常见于免疫抑制患者。在免疫功能正常的患者中极为罕见。
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