Department of Neurosurgery, Traditional Chinese Medical Hospital of Zhejiang Province, 54 Youdian Road, Hangzhou 310006, China.
Peptides. 2012 Feb;33(2):336-41. doi: 10.1016/j.peptides.2012.01.011. Epub 2012 Jan 24.
High plasma copeptin levels have been found to be associated with short-term poor outcome after intracerebral hemorrhage (ICH). We furthermore evaluate the relation of plasma copeptin levels to long-term outcome and early neurological deterioration after ICH. Fifty healthy controls and 89 patients with acute spontaneous basal ganglia hemorrhage were recruited in this study. Plasma copeptin concentrations on admission measured by enzyme-linked immunosorbent assay were considerably high in patients than healthy controls. A multivariate analysis identified plasma copeptin level as an independent predictor for 1-year mortality, 1-year unfavorable outcome (modified Rankin Scale score>2) and early neurological deterioration. A receiver operating characteristic curve showed that the predictive value of plasma copeptin concentration was similar to that of National Institutes of Health Stroke Scale scores for long-term poor outcome and early neurological deterioration. However, copeptin did not obviously improve the predictive values of National Institutes of Health Stroke Scale scores. Thus, increased plasma copeptin level is an independent prognostic marker of 1-year mortality, 1-year unfavorable outcome and early neurological deterioration after ICH.
高血浆 copeptin 水平与脑出血（ICH）后短期预后不良相关。我们进一步评估了血浆 copeptin 水平与 ICH 后长期预后和早期神经功能恶化的关系。本研究纳入了 50 名健康对照者和 89 名急性自发性基底节出血患者。酶联免疫吸附试验检测入院时的血浆 copeptin 浓度在患者中明显高于健康对照组。多变量分析确定血浆 copeptin 水平是 1 年死亡率、1 年不良预后（改良 Rankin 量表评分>2）和早期神经功能恶化的独立预测因子。受试者工作特征曲线显示，血浆 copeptin 浓度的预测价值与国立卫生研究院卒中量表评分对长期预后不良和早期神经功能恶化的预测价值相似。然而，copeptin 并没有明显提高国立卫生研究院卒中量表评分的预测值。因此，血浆 copeptin 水平升高是 ICH 后 1 年死亡率、1 年不良预后和早期神经功能恶化的独立预后标志物。
