Vasile Antonia Ioana, Tuță Sorin, Tiu Cristina, Badiu Corin
Doctoral School, Carol Davila University of Medicine and Pharmacy, 030167 Bucharest, Romania.
Neurology Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania.
Int J Mol Sci. 2025 Jun 1;26(11):5328. doi: 10.3390/ijms26115328.
Diagnosis in stroke patients is based mainly on clinical and radiological findings; therefore, there is a need for serological markers that can orient the clinician. Copeptin is a new blood marker for diagnosis and prognosis in several neurological conditions, such as ischemic stroke, hemorrhagic stroke, aneurysmal subarachnoid hemorrhage, and multiple sclerosis. The aim of our study was to highlight the diagnostic value of copeptin in differentiating between stroke subtypes and stroke mimics. We performed a literature review by searching the PubMed and Scopus databases for papers with the following keywords: "stroke AND copeptin AND differential". The PRISMA criteria were used. We identified 29 papers that met the criteria. We analyzed only original research articles, excluding reviews and only including those in English. Some studies did not find any significant differences between cerebral infarction, intracerebral hemorrhage, and subarachnoid hemorrhage, but one study demonstrated significant correlations. All studies agreed that copeptin levels can help in differentiating stroke patients from stroke-free patients. Copeptin levels were correlated with prognostic scales For stroke mimics, copeptin levels were extremely broad and for vestibular disorders; it was shown that a normal level of copeptin excludes stroke. Copeptin is a new blood marker that can help clinicians in the acute neurological field. It may help in diagnosing stroke, in differentiating between stroke subtypes and stroke mimics, and in evaluating the prognosis of these patients, but further studies are needed.
中风患者的诊断主要基于临床和影像学检查结果；因此，需要血清学标志物来为临床医生提供指导。 copeptin是一种新的血液标志物，可用于多种神经系统疾病的诊断和预后评估，如缺血性中风、出血性中风、动脉瘤性蛛网膜下腔出血和多发性硬化症。我们研究的目的是突出copeptin在区分中风亚型和类中风疾病方面的诊断价值。我们通过在PubMed和Scopus数据库中搜索包含以下关键词的论文进行文献综述：“中风 AND copeptin AND 鉴别”。使用了PRISMA标准。我们确定了29篇符合标准的论文。我们仅分析原创研究文章，排除综述且只纳入英文文章。一些研究未发现脑梗死、脑出血和蛛网膜下腔出血之间有任何显著差异，但有一项研究显示存在显著相关性。所有研究均认为copeptin水平有助于区分中风患者和非中风患者。copeptin水平与预后量表相关。对于类中风疾病，copeptin水平范围极广，对于前庭疾病，研究表明copeptin水平正常可排除中风。copeptin是一种新的血液标志物，可帮助急性神经科领域的临床医生。它可能有助于诊断中风、区分中风亚型和类中风疾病以及评估这些患者的预后，但仍需要进一步研究。
