Goyal Tanu, Mitra Sona, Khaidakov Magomed, Wang Xianwei, Singla Sandeep, Ding Zufeng, Liu Shijie, Mehta Jawahar L
University of Arkansas for Medical Sciences and Central Arkansas Veterans Health System, Little Rock, AR, USA,
Curr Atheroscler Rep. 2012 Jan 29. doi: 10.1007/s11883-012-0228-1.
Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.
动脉粥样硬化的特征是脂质和炎症细胞在动脉壁内积聚。氧化型低密度脂蛋白（ox-LDL）在动脉粥样斑块的发生和发展中起重要作用。在过去二十年中，已识别出多种清道夫受体，它们介导ox-LDL的摄取，导致泡沫细胞形成。已表明抑制清道夫受体A和CD36可通过减少泡沫细胞形成来影响动脉粥样硬化的进展。凝集素型氧化LDL受体1（LOX-1）参与动脉粥样硬化发病机制的各个步骤，在实验研究中，其阻断已显示可在多个水平上影响动脉粥样硬化的进展。在本综述中，我们总结了ox-LDL和清道夫受体在动脉粥样瘤形成中的作用，重点是LOX-1阻断的作用。
