Palmisano J M, Martin J M, Krauzowicz B A, Truman K H, Meliones J N
Department of Pediatric Cardiology, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor 48109-0204.
Heart Lung. 1990 Nov;19(6):627-30.
In patients with pulmonary disease, pulmonary artery hypertension often occurs as a result of pulmonary artery vasoconstriction, primarily from hypoxia and alveolar hypotension. In this report we describe the hemodynamic effects of breathing supplemental oxygen in a child with bronchopulmonary dysplasia and pulmonary artery hypertension. These hemodynamic effects include an improvement in oxygenation, an increase in systemic vascular resistance, and a decrease in the pulmonary vascular resistance. As a direct result of these changes in vascular resistances, alterations of heart rate, cardiac index, stroke volume, aortic pressure, oxygen consumption, and pulmonary artery pressure have been shown to occur. Oxygen is widely used to treat many physiologic conditions. However, during the administration of supplemental oxygen, rarely do we recognize the hemodynamic changes associated with its use. These hemodynamic effects must be clearly understood and appreciated before oxygen administration in any clinical situation.
在患有肺部疾病的患者中，肺动脉高压常因肺动脉血管收缩而发生，主要是由缺氧和肺泡低血压引起的。在本报告中，我们描述了呼吸补充氧气对一名患有支气管肺发育不良和肺动脉高压儿童的血流动力学影响。这些血流动力学影响包括氧合改善、全身血管阻力增加和肺血管阻力降低。由于这些血管阻力的变化，已显示心率、心脏指数、每搏量、主动脉压、氧耗量和肺动脉压会发生改变。氧气被广泛用于治疗许多生理状况。然而，在给予补充氧气期间，我们很少认识到与其使用相关的血流动力学变化。在任何临床情况下给予氧气之前，必须清楚地理解和认识这些血流动力学影响。
