Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, 50028 Kaunas, Lithuania.
Medicina (Kaunas). 2011;47(11):595-9.
The aim of this prospective randomized study was to evaluate the impact of different sharp-edged intraocular lenses (IOLs) (hydrophobic acrylic or silicone) on posterior and anterior lens capsule opacification (PCO and ACO) at 3-year postoperative follow-up.
A total of 96 eyes (89 patients) having a standard uncomplicated phacoemulsification procedure for age-related cataract were included in a prospective clinical study: 34 eyes with a 3-piece acrylic hydrophobic (AcrySof, MA3OBA), 32 eyes with a 1-piece acrylic hydrophobic (AcrySof, SA3OAL), and 30 eyes with a 3-piece silicone (CeeOn 911A) IOL. Visual acuity, capsulorrhexis/optic overlapping, ACO and PCO (using EPCO2000 system) were evaluated at 3-year follow-up. Capsulotomies performed by means of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser were recorded.
Three years after surgery, the grade of ACO of the capsulorrhexis rim area and the capsule/optic area was significantly greater in the silicone IOL group than in the acrylic IOL groups (P<0.05). During 3 postoperative years, there were no significant differences in the PCO values either in the entire IOL optic area or in the central 3-mm optic zone comparing the groups. Three years after surgery, 9% of eyes with a 3-piece acrylic IOL, 3.1% of eyes with a 1-piece acrylic IOL, and no case in the silicone IOL group had Nd:YAG capsulotomy (P>0.05).
The 3-year follow-up after cataract surgery showed no difference in PCO development (EPCO2000) between acrylic hydrophobic and silicone sharp-edged IOLs. However, the need for Nd:YAG laser capsulotomy was higher in the acrylic IOL groups than the silicone IOL group, though the difference was not significant. ACO was greatest in the eyes with 3-piece silicone IOLs.
本前瞻性随机研究旨在评估不同锐边人工晶状体（IOL）（疏水性丙烯酸或硅酮）对术后 3 年时后囊膜混浊（PCO 和 ACO）的影响。
共纳入 96 只眼（89 例患者）进行年龄相关性白内障的标准超声乳化术：34 只眼植入 3 件式疏水性丙烯酸（AcrySof，MA3OBA），32 只眼植入 1 件式疏水性丙烯酸（AcrySof，SA3OAL），30 只眼植入 3 件式硅酮（CeeOn 911A）IOL。术后 3 年评估视力、囊膜切开/光学重叠、ACO 和 PCO（使用 EPCO2000 系统）。记录使用钕钇铝石榴石（Nd：YAG）激光进行的囊膜切开术。
术后 3 年时，囊膜切开缘和囊膜/光学区的 ACO 分级在硅酮 IOL 组显著高于丙烯酸 IOL 组（P<0.05）。术后 3 年时，各组之间整个 IOL 光学区或中央 3mm 光学区的 PCO 值均无显著差异。术后 3 年时，3 件式丙烯酸 IOL 组有 9%的眼、1 件式丙烯酸 IOL 组有 3.1%的眼需要进行 Nd：YAG 囊膜切开术，而硅酮 IOL 组无一例需要（P>0.05）。
白内障手术后 3 年的随访结果显示，疏水性丙烯酸和硅酮锐边 IOL 后囊膜混浊（EPCO2000）的发展无差异。然而，与硅酮 IOL 组相比，丙烯酸 IOL 组需要 Nd：YAG 激光囊膜切开术的比例更高，但差异无统计学意义。3 件式硅酮 IOL 组的 ACO 最大。
