Faculty of Pharmacy, Université de Montréal, succursale Centre-ville, C.P. 6128, Montréal, QC, H3C 3J7, Canada.
Eur J Epidemiol. 2012 Mar;27(3):205-14. doi: 10.1007/s10654-012-9654-1.
There are conflicting results concerning the impact of maternal asthma during pregnancy on perinatal outcomes. The present study investigated the associations between maternal asthma during pregnancy and the risk of a small-for-gestational-age (SGA) infant, a low-birth-weight (LBW) infant, and preterm birth. A population-based cohort of 40,788 pregnancies from asthmatic and non-asthmatic women was reconstructed through the linking of three Quebec (Canada) administrative databases between 1990 and 2002. A two-stage sampling cohort design was used to collect additional information by way of a mailed questionnaire. The generalized estimation equation models were used to obtain adjusted odds ratios of SGA, LBW and preterm birth comparing asthmatic and non-asthmatic women. The cohort included 13,007 pregnancies from asthmatic and 27,781 pregnancies from non-asthmatic women. Final estimates showed that the odds of SGA (odds ratio: 1.27, 95% confidence interval: 1.14, 1.41), LBW (1.41: 1.22, 1.63) and preterm delivery (1.64: 1.46, 1.83) were significantly higher among asthmatic than non-asthmatic women. Mothers with asthma during pregnancy are more likely to have SGA, LBW, or preterm birth infants than non-asthmatic women. These results can be more easily generalized to women with lower socio-economic status since the cohort under represents women with high socio-economic status.
关于母亲怀孕期间哮喘对围产期结局的影响，结果相互矛盾。本研究调查了怀孕期间哮喘与胎儿生长受限（SGA）婴儿、低出生体重（LBW）婴儿和早产风险之间的关联。通过在 1990 年至 2002 年间链接三个魁北克（加拿大）行政数据库，重建了一个由哮喘和非哮喘女性组成的 40788 例妊娠的基于人群的队列。采用两阶段抽样队列设计，通过邮寄问卷收集了额外信息。使用广义估计方程模型获得了比较哮喘和非哮喘女性的 SGA、LBW 和早产的调整比值比。该队列包括来自哮喘的 13007 例妊娠和来自非哮喘的 27781 例妊娠。最终估计表明，SGA（比值比：1.27，95%置信区间：1.14，1.41）、LBW（1.41:1.22,1.63）和早产（1.64:1.46,1.83）的可能性在哮喘女性中明显高于非哮喘女性。与非哮喘女性相比，怀孕期间患有哮喘的母亲更有可能生育 SGA、LBW 或早产婴儿。由于该队列代表性不足，这些结果更容易推广到社会经济地位较低的女性，因为这些女性具有较高的社会经济地位。
