Bailleux A, Brennwald J, Rosso R, Aebi M, Regazzoni P
Departement Chirurgie der Universität, Kantonsspital Basel.
Helv Chir Acta. 1990 Jun;57(1):79-82.
Fresh allogeneic diaphyseal bone segments were transplanted into 12 dogs. We attempted to improve the immunogenity and incorporation of the bone segments through "graft manipulation" with and without immunosuppression. Through clinical and radiological study during the 20-week experimental period, we observed transplant healing with differing structural phenomena. After autologous knee joint replantation in 4 dogs and allogeneic transplantation in 2 dogs (with and without revascularization and immunomodulation with Cyclosporin A) we present a canine model to investigate all open questions about the transplantation of allogeneic, fresh joints (i.e. transplant biology, immunology, and vitality).
将新鲜的同种异体骨干段移植到12只犬体内。我们试图通过有或没有免疫抑制的“移植物处理”来改善骨段的免疫原性和整合情况。在为期20周的实验期内，通过临床和放射学研究，我们观察到移植愈合伴有不同的结构现象。在4只犬进行自体膝关节再植以及2只犬进行同种异体移植（有或没有血管再通以及用环孢素A进行免疫调节）后，我们提出了一个犬模型，以研究关于同种异体新鲜关节移植的所有未解决问题（即移植生物学、免疫学和活力）。
