Redmond J, Cros D, Shahani B T
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Henry Ford Hosp Med J. 1990;38(1):62-7.
The conventional estimation of motor, sensory, and mixed nerve conduction velocities reflects activity in the fastest conducting, heavily myelinated nerve fibers that are only a small proportion of the total. Unmyelinated and thinly myelinated fibers are not evaluated by this technique and numerically represent the largest group of fibers in human cutaneous nerves. The availability of new quantitative techniques to study this aspect of sensory function is an important addition to standard electrodiagnosis. Patient understanding and cooperation is essential because subjective responses are evaluated. We evaluated a reference range for 20 healthy subjects as well as variability on repeated testing. Vibration and thermal thresholds were measured bilaterally at several sites. Measurements were repeated at intervals ranging from two days to three months. There was no side difference but substantial site differences were noted for all measurements. Intraindividual variation was substantial but within the expected range for a psychophysiologic test. Close correlation was noted between various measurements at same and different sites, indicating a great degree of interindividual variation. The Marstock method is recommended for routine clinical use.
传统的运动、感觉及混合神经传导速度估计反映的是传导速度最快、髓鞘厚的神经纤维的活动，而这些纤维在总数中仅占一小部分。无髓鞘和薄髓鞘纤维无法通过该技术进行评估，但其数量在人体皮神经纤维中占比最大。研究感觉功能这一方面的新定量技术的出现，是对标准电诊断的重要补充。由于要评估主观反应，患者的理解与配合至关重要。我们评估了20名健康受试者的参考范围以及重复测试时的变异性。在多个部位双侧测量振动和温度阈值。测量间隔时间从两天到三个月不等。所有测量均未发现左右差异，但部位差异显著。个体内变异很大，但在心理生理测试的预期范围内。同一部位和不同部位的各种测量之间存在密切相关性，表明个体间差异很大。推荐使用马斯托克方法进行常规临床应用。
