Division of Rhinology, Allergy, and Sinus Surgery, University of North Carolina at Chapel Hill, NC 27599-7070, USA.
Int Forum Allergy Rhinol. 2011 May-Jun;1(3):161-6. doi: 10.1002/alr.20029. Epub 2011 Apr 26.
Endoscopic, endonasal, minimally invasive pituitary surgery (MIPS) has proven to be safe and efficacious. However, there are few data that assess the health-related or sinonasal-specific quality-of-life (QoL) of those undergoing MIPS. Our hypothesis is that patients undergoing MIPS do not have significantly different sinus disability or change in QoL after surgery compared to prior to surgery.
This is a retrospective review of patients undergoing MIPS between 2002 and 2009. Rhinosinusitis Disability Index (RSDI) scores, patient demographics, tumor characteristics, surgical outcomes, and intraoperative/postoperative complications were recorded. Preoperative and postoperative mean RSDI scores and the mean absolute change in RSDI were calculated with 95% confidence intervals (CIs). One-way analysis of variance (ANOVA) compared RSDI scores between different tumor subgroups.
A total of 50 patients completed the RSDI preoperatively and postoperatively. Analyses revealed no significant difference between preoperative and postoperative scores across all domains (p = 0.84). When the cohort was stratified into functional vs nonfunctional tumor types there was no significant difference between the 2 groups (p = 0.88). Data showed no statistically significant change in RSDI scores postoperatively in all groups.
These data show that MIPS with appropriate postoperative care results in little or no long-term sinonasal quality of life defects.
经鼻内镜微创手术（MIPS）已被证明是安全有效的。然而，评估接受 MIPS 治疗的患者健康相关或鼻-鼻窦特定生活质量（QoL）的数据很少。我们的假设是，与术前相比，接受 MIPS 治疗的患者在手术后鼻窦功能障碍或 QoL 没有明显差异。
这是一项对 2002 年至 2009 年间接受 MIPS 治疗的患者进行的回顾性研究。记录了鼻-鼻窦炎患者生活质量问卷（RSDI）评分、患者人口统计学资料、肿瘤特征、手术结果和术中/术后并发症。计算了术前和术后平均 RSDI 评分以及 RSDI 的平均绝对变化，并计算了 95%置信区间（CI）。单因素方差分析（ANOVA）比较了不同肿瘤亚组之间的 RSDI 评分。
共有 50 例患者完成了 RSDI 的术前和术后评估。分析显示，所有领域的术前和术后评分均无显著差异（p=0.84）。当将队列分为功能性和非功能性肿瘤类型时，两组之间无显著差异（p=0.88）。数据显示，所有组术后 RSDI 评分均无统计学意义的变化。
这些数据表明，MIPS 结合适当的术后护理，很少或不会导致长期的鼻-鼻窦生活质量缺陷。
