Tomoum Mohamed O, Klattcromwell Cristine, DelSignore Anthony, Ebert Charles, Senior Brent A
University of North Carolina at Chapel Hill, Otolaryngology/Head and Neck Surgery, Chapel Hill, NC.
Tanta University, Otolaryngology/Head and Neck Surgery, Tanta, El-Gharbiya, Egypt.
Int Forum Allergy Rhinol. 2015 Aug;5(8):674-81. doi: 10.1002/alr.21528. Epub 2015 May 7.
Both depression and anxiety have been suspected to impact quality of life adversely in patients with chronic rhinosinusitis (CRS). The objective of this work was to assess for the presence of anxiety and/or depression in the setting of CRS and to assess their impact on disease-related quality of life by analyzing the correlation between the Rhinosinusitis Disability Index (RSDI) and the Hospital Anxiety and Depression score (HADS), as well as the Lund-Kennedy nasal endoscopic scores.
A total of 124 patients with CRS were prospectively evaluated in the outpatient setting using the RSDI and HADS questionnaires as well as the Lund-Kennedy nasal endoscopy scoring system.
The total RSDI and its subscale scores had moderate to very strong correlation with the HADS total score and each of its subscale scores in comparison to their poor correlation with Lund-Kennedy endoscopic score. CRS patients with depression or anxiety scores 8 to 10 (possible case of clinically significant depression or anxiety) and 11 to 21 (probable case) reported worse total RSDI and subscale scores when compared with those with normal scores (0 to 7). There was no significant difference in the Lund-Kennedy endoscopic scores between the different groups of anxiety and depression scores.
Depression and anxiety are prevalent in CRS. The total RSDI and its different subscale scores exhibit moderate to very strong correlation with depression/anxiety scores as determined by HADS, whereas poor correlation was seen with the Lund-Kennedy endoscopic score.
抑郁症和焦虑症均被怀疑会对慢性鼻-鼻窦炎（CRS）患者的生活质量产生不利影响。本研究的目的是评估CRS患者中焦虑症和/或抑郁症的存在情况，并通过分析鼻窦炎残疾指数（RSDI）与医院焦虑抑郁量表得分（HADS）以及Lund-Kennedy鼻内镜评分之间的相关性，来评估它们对疾病相关生活质量的影响。
总共124例CRS患者在门诊环境中接受前瞻性评估，使用RSDI和HADS问卷以及Lund-Kennedy鼻内镜评分系统。
与RSDI总分及其各子量表得分与Lund-Kennedy内镜评分的低相关性相比，RSDI总分及其各子量表得分与HADS总分及其各子量表得分具有中度至非常强的相关性。与正常评分（0至7）的患者相比，抑郁或焦虑评分为8至10分（可能存在临床显著抑郁或焦虑）以及11至21分（很可能存在）的CRS患者报告的RSDI总分及子量表得分更差。不同焦虑和抑郁评分组之间的Lund-Kennedy内镜评分无显著差异。
抑郁症和焦虑症在CRS中很常见。RSDI总分及其不同子量表得分与由HADS确定的抑郁/焦虑评分呈现中度至非常强的相关性，而与Lund-Kennedy内镜评分的相关性较差。
