Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Gyeonggi-Do, Republic of Korea.
Anticancer Res. 2012 Feb;32(2):589-94.
BACKGROUND/AIM: We aimed to investigate the prognostic value of biomarkers [Ki-67, adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1), adenosine triphosphate-binding cassette sub-family C member 1 (ABCC1), adenosine triphosphate-binding cassette sub-family C member 2 (ABCC2), p53, cyclin E and v-akt murine thymoma viral oncogene homolog 2 (AKT2)] in patients with advanced epithelial ovarian cancer (EOC).
The levels of expression of biomarkers in tumor tissues of 47 patients with stage 3 or 4 EOC were estimated via immunohistochemical staining using tissue microarrays. The associations of biomarker expression with progression-free survival (PFS) and overall survival (OS) were evaluated using a log-rank test and Cox regression analysis.
Based on multivariate analysis, high expression of Ki-67 (p=0.003) and low expression of ABCC2 (p=0.048) were associated with a prolonged PFS. However, other biomarkers were not associated with PFS. Residual tumor <1 cm (p=0.023) and PFS >6 months (p=0.005) were associated with prolonged OS. However, none of the biomarkers were associated with OS.
High expression of Ki-67 and low expression of ABCC2 appear to be useful as markers for prolonged PFS in patients with advanced EOC.
背景/目的：我们旨在研究生物标志物[Ki-67、三磷酸腺苷结合盒亚家族 B 成员 1（ABCB1）、三磷酸腺苷结合盒亚家族 C 成员 1（ABCC1）、三磷酸腺苷结合盒亚家族 C 成员 2（ABCC2）、p53、细胞周期蛋白 E 和 v-akt 鼠胸腺瘤病毒癌基因同源物 2（AKT2）]在晚期上皮性卵巢癌（EOC）患者中的预后价值。
使用组织微阵列通过免疫组织化学染色评估 47 例 3 或 4 期 EOC 患者肿瘤组织中生物标志物的表达水平。使用对数秩检验和 Cox 回归分析评估生物标志物表达与无进展生存期（PFS）和总生存期（OS）的相关性。
基于多变量分析，Ki-67 高表达（p=0.003）和 ABCC2 低表达（p=0.048）与 PFS 延长相关。然而，其他生物标志物与 PFS 无关。残留肿瘤<1cm（p=0.023）和 PFS>6 个月（p=0.005）与 OS 延长相关。然而，没有一种生物标志物与 OS 相关。
Ki-67 高表达和 ABCC2 低表达似乎可作为晚期 EOC 患者 PFS 延长的有用标志物。
